In recent years, there has been a significant focus on improving the effectiveness of radiotherapy (RT) and particle therapy in treating tumors while minimizing damage to healthy tissue. A promising development is offered by the observation of the so-called FLASH effect, where ultra -high dose rates delivered in a short time have shown to protect healthy tissues while maintaining anti -tumor efficacy. However, conventional detectors face challenges in monitoring charged beams at these ultra -high dose rates due to non-linear effects. To address this challenge, the FlashDC (Flash Detector beam Counter) has been developed. It uses air fluorescence to monitor beam fluence and spatial distribution in real-time with high accuracy and minimal impact on treatment delivery. This innovative detector offers a linear response for various charged beams, dose rates, and energies, making it a cost-effective solution. Multiple prototypes have been developed and optimized using Monte Carlo simulations. The analysis of data from recent test beam campaigns with electrons delivered at FLASH intensities has demonstrated a linear correlation between the detector signal and the delivered dose per pulse, confirming that fluorescence can be used for beam monitoring in FLASH-RT studies. This contribution introduces the FlashDC monitor, discusses its expected performance, and presents preliminary test beam results obtained with electron beams in FLASH mode.

Test beam results of a fluorescence-based monitor for ultra-high dose rates

Garbini M;Marafini M;
2024-01-01

Abstract

In recent years, there has been a significant focus on improving the effectiveness of radiotherapy (RT) and particle therapy in treating tumors while minimizing damage to healthy tissue. A promising development is offered by the observation of the so-called FLASH effect, where ultra -high dose rates delivered in a short time have shown to protect healthy tissues while maintaining anti -tumor efficacy. However, conventional detectors face challenges in monitoring charged beams at these ultra -high dose rates due to non-linear effects. To address this challenge, the FlashDC (Flash Detector beam Counter) has been developed. It uses air fluorescence to monitor beam fluence and spatial distribution in real-time with high accuracy and minimal impact on treatment delivery. This innovative detector offers a linear response for various charged beams, dose rates, and energies, making it a cost-effective solution. Multiple prototypes have been developed and optimized using Monte Carlo simulations. The analysis of data from recent test beam campaigns with electrons delivered at FLASH intensities has demonstrated a linear correlation between the detector signal and the delivered dose per pulse, confirming that fluorescence can be used for beam monitoring in FLASH-RT studies. This contribution introduces the FlashDC monitor, discusses its expected performance, and presents preliminary test beam results obtained with electron beams in FLASH mode.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14249/290
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